Contributions to the study of potential physiologic and physiopatho logic consequences of axial accumulation of bloodcells elements. Part Two: biomechanical analysis enlarged

Abstract

Both in-vitro and in-vivo observations and experiments show that the radial distribution of formed elements in blood flowing in arteries is, under certain circumstances, not uniform. This non-uniform distribution of blood cells is related with a spatial variation in blood viscosity and modifications in blood shear rates. The variations both in shear rates and in blood cell concentra-tions near the endothelium, modifies fluid-to-wall mass transport processes in arteries. The purpose of this second part of the article is: (a) Discuss conditions for in vivo appearance of the axial accu-mulation o f red cells, considered as one of the self-fluidization mechanisms of moving blood in the arterial conduits. (b) Analyze possible consequences and physiological and pathological interrelationships of this phenomenon. Some biomechanical aspects of growth, remodeling and damage in arterial walls during the life cycle are considered.