Comparación de subtipos histológicos y genotipos del virus del papiloma humano (VPH) en la neoplasia intraepitelial del pene (PEIN) con y sin carcinoma escamoso invasivo: un estudio de 76 lesiones en 43 pacientes utilizando microdisección por captura láser y PCR
DOI:
https://doi.org/10.32480/rscp.2026.e3118Palabras clave:
Neoplasia de pene, carcinoma de células escamosas, neoplasia intraepitelial de pene, virus del papiloma humano, microdisección láserResumen
La neoplasia intraepitelial de pene (PeIN) y el carcinoma de pene invasivo presentan un perfil bimodal: VPH-independiente y VPH-asociado. La PeIN puede ocurrir como lesión aislada o asociada a carcinoma invasivo. Este estudio compara los subtipos histológicos y los genotipos de VPH entre ambos grupos. Se evaluaron 40 lesiones de PeIN aisladas (17 pacientes) y 36 lesiones de PeIN asociadas a carcinoma invasivo (26 pacientes). Las lesiones se clasificaron como VPH-independientes (diferenciada), VPH-asociadas (basaloide, warty-basaloide, warty) o mixtas. Se realizó microdisección por captura láser (LCM) y genotipificación con el sistema SPF-10/DEIA/LiPA25. La PeIN diferenciada fue significativamente más frecuente en los casos con carcinoma invasivo, mientras que la PeIN VPH-asociada predominó en las lesiones aisladas Se detectó mayor diversidad de genotipos VPH en PeIN aislada (15 vs 6 genotipos). Genotipos exclusivos de PeIN aislada incluyeron VPH 30, 33, 35, 39, 44, 58, 66, 73, 84, 87, 51 y 59; los exclusivos de PeIN con carcinoma invasivo fueron VPH 11, 18 y 74. VPH 16, 52 y 56 fueron comunes a ambos grupos. La falta de correspondencia de los subtipos histológicos y genotipos detectados entre las PeIN aisladas y las asociadas a carcinoma sugiere que varias lesiones PeIN aisladas no progresan a carcinoma invasivo.
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