Micronúcleo en células exfoliadas orales y factores asociados en jóvenes adultos en el extremo sur de Brasil
DOI:
https://doi.org/10.32480/rscp.2021.26.2.150Palabras clave:
ensayo de micronúcleos, daño al ADN, biomarcador, adultos jóvenesResumen
Existe un interés creciente en la aplicación de ensayos de micronúcleos (MN) en el entorno clínico para invertir el impacto de las condiciones ambientales, genéticas, de estilo de vida y socioeconómicas en el ADN. Sin embargo, no se ha estudiado la evaluación del daño mutagénico en población joven y la intervención temprana en esta población puede prevenir varias comorbilidades de salud. Así, el presente estudio tuvo como objetivo investigar la presencia de MN en adultos jóvenes y sus factores asociados. Se trata de un estudio transversal, compuesto por 155 adultos jóvenes (entre 18 y <30 años) de ambos sexos. Los datos socioeconómicos y de estilo de vida se recopilaron mediante un cuestionario semiestructurado. Se recolectaron células exfoliadas orales para evaluar la frecuencia de células MN. Las condiciones socioeconómicas y los factores del estilo de vida no se asociaron con la presencia de MN. El veinte por ciento de los participantes reportó alguna enfermedad crónica no transmisible y casi doce por ciento reportaron uso continuado de medicación, ambas variables presentan un factor de riesgo para la prevalencia de NM. Si bien la mutagénesis es un proceso generalmente más relacionado con las personas mayores, este estudio destaca la importancia de monitorear el daño del ADN entre los adultos jóvenes y promover hábitos saludables para prevenir el desarrollo y peor pronóstico de enfermedades crónicas no transmisibles y el consecuente uso de medicamentos.
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